The Endocannabinoid System

What is the Endocannabinoid System?

This Endocannabinoid system can be hard to pronounce, let alone explain.

If you can wrap your head around this you will see why CBD can help us so much. It is unlikely that you heard of this system. While we were in school we all got the 101 on the Digestive and Nervous systems. The endocannabinoid system was not discovered until 1990. This fact has contributed to the stigma associated with CBD and Cannabis. We thought we knew the body’s systems inside and out. The endocannabinoid system is specialized in the human body embracing a network of cannabinoid receptors but every mammal has one of these systems. You can read below or you can check out the videos which explain the system in a lot more detail.

The Public Stigma

There is a lot of science behind this and CBD is going to be around for a long time as the public starts to understand that this is not just some fad and big Pharma is lying and downplaying this amazing Plant called Cannabis. This system is all over our bodies and explains why CBD has such a profound benefit on our bodies. This is both its biggest strength and weakness when it comes to the general public. The fact it can help with so many physical and mental issues has everyone thinking it can’t be that true. If you can take some time out to understand this system, you will understand that CBD is one of the best things you can give yourself when it comes to maintaining your overall health.

Soon CBD and Cannabis will take over your daily multi-vitamin. When you see the big changes in your family’s overall health, you will wonder why you didn’t take CBD before. Your Doctor/Gp visits decrease and you will wonder why you didn’t take CBD before. The Pharma drugs you used before will no longer seem so important and you will wonder why you have not taken CBD before.


The Endocannabinoid System
The Endocannabinoid System


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DR. Mechoulam and his team isolated cannabidiol and THC. THC lodges in a specific receptor which is located in the brain. This was then named Cannabinoid Receptor type 1, or CB1. Another receptor was located in the immune system and this was called the Cannabinoid Receptor Type 2, or CB2. This was only discovered in the ’90s.

Why were these here?

The research continued and the cannabis plant was found to react with these receptors. This then led to the name ENDOCANNABINOIDS and it has been called this ever since. It is of course slightly more complicated than this but let not make it confusing. The above is heavily researched. Again, don’t my word for it. Please look into this yourself. If you do, you will see why CBD could play such a huge role in your life and why we all should be taking this supplement daily.

1.The Endocannabinoid System and Endocannabinoids (eCBs)

Anandamide. This means supreme joy. It also has been given the name the “bliss” chemical. When people see something nice that they want and then they eat it this is the chemical that is released. It works with the CB1 receptors only.

Endocannabinoids display unique properties:

The endocannabinoids or ECBS are unique. The information from the brain to the cells usually goes one way. The chemicals released from the brain would flow from here to the target nerve cell. The ECBS flows the other way and this is truly unique. They then connect to the CB1 receptors and block the flow of other chemicals. Once they do their job they are then broken down and they flow back into the system. They only work for a short period of time. The body can make these chemicals up but not on-demand and in large quantities and like protein we need to ingest this compound if we want to feel the benefits. We need protein to build muscle and we think you need CBD to sustain a healthy body also and it should not underestimate how important a role CBD can make to your overall health.




The Endocannabinoid system

2. CB1 Receptors in The Endocannabinoid system

CB1 receptors are present in the:

1. Brain (distributed throughout the brain)
2. Fat cells
3. Muscles Gut
4. Liver
5. Thyroid and adrenal glands
6. Male and female reproductive systems
7. Lungs
8. Kidneys

CBD and the Menstrual Cycle

You have now started to see that the Endocannabinoid System is an important part of your genetic makeup. This system is helping you to maintain a healthy body, spirit, and mind.

You may turn to CBD to help you with issues that are occurring in your life but in my opinion, prevention is better than cure. This is another reason why this supplement should be taken daily as part of your routine.

CBD could be a great way to help with the menstrual cycle. There are many receptors in this area and as a result, this could help with the negative reactions associated with this monthly event.

The Build-Up Of Body Fat.

Don’t go buying CBD thinking you are going to shed loads of pounds as nothing has been proven on humans and it is NOT going to happen. I mention this here as the CB1 receptors are located on our fat cells. If these cells are under or overactive CBD may help them get back into their normal states. This could help regulate the cells and provide balance. Scientists are looking into this as a means of controlling obesity. At the end of the day that process all comes down to the balance of what is going into the body versus what is going out and this can never be avoided no matter what type of herb, oil, or drink you consume.

Relief From Anxiety & Triggering Anxiety

When we feel anxious or overstimulated due to the brain releasing certain chemicals or hormones, we often go to a GP who would prescribe medications to deal with this.

Sickness, in its many forms, often occurs due to a build of negative circumstances. We are merely looking to treat the aftermath. There are many ways we can reduce the frequency of this. A well-balanced diet, keeping hydrated and other things like meditation. Of course CBD, in my opinion, has an advantage as it is working with your body’s needs and is helping to reduce or prevent this from occurring.


CBD has been shown to suppress the chemicals/hormones that overstimulate the body and block them from doing this. This, of course, is good news for us if we are looking to get a good night’s sleep or stay relaxed and calm throughout our lives.



Slowing Down The Firing Of The Nerve Cells

When someone has a seizure the brain is firing too much. CBD interacts by stopping these cells from firing too much which can reduce the attacks. Cannabis oil, which is basically CBD with an extra Cannabinoid THC, has been seen to be effective in children’s epilepsy. There are however many types of this and every person who has this is unique in the sense that their triggers differ. This means the strain and dosage can differ. My wife has epilepsy and we do not doubt that CBD helps with her triggers which are lack of sleep and stress.

It would also stand to reason, in my opinion, why I constantly get the feedback –

“Marc, I can’t put my finger on it. I’m just more relaxed and things that used to bother me don’t and people are saying I look better. It must be doing something”

Modifying Your Sensitivity To Pain

CB1 receptors are located in the spinal cord. We, of course, all know that this is the heart of the nerve system. When pain is sent to and from this area it can be dulled or lost as the signals are suppressed. This is why it could help with pain management. What many don’t realize is, pain is the body’s way of telling you something is wrong. We should always be looking at the route causes of our issues.

It is why so many people are surprised when I often look deeper into their issues to try and get to the heart of the problem. (I have a background in Fitness and Nutrition)

Connecting The Brain And Gut

The Endocannabinoid system is the axis from where the brain talks to the stomach. Stress is a key factor in IPS or Irritable Bowel Syndrome. If these stress hormones are in balance your IPS can be reduced. Your gut plays a huge role in your well being.



3. CB2 Receptors in The Endocannabinoid system

Just like the CB1 receptors the CB2 receptors will work and interact with certain parts of the body. Think of it in terms of two keys with two locks. These systems are mainly located in other parts of the body such as –

1. The digestive tract
2. Bone marrow
3. The immune system
4. The spleen
5. The tonsils

Combating inflammation

When we are sick inflammation occurs somewhere in the body. This is our internal system fighting back to try and heal and repair those damage or sick systems. CBD works with the immune cells and the CB2 receptors can kick start these cells to help them fight off any inflammation. Therefore CBD can help in many ways. For example, it can have a positive effect on your bowels and gut and reduce problems that may occur here.

Maintaining heart health

CB2 receptors also work well with the heart. This is a large muscle that is constantly working under pressure. CBD is heart-friendly. It can aid in the reduction and slow down the build-up of fatty plaques in your arteries. The build of these plaques causes heart disease.

Supporting bone health

CBD works with the cells in form bone. It helps with the creation of bone cells and helps stop the creation of cells that break down the bone.

Controlling nausea and vomiting

Again the CBD receptors that live and thrive in the brain are also based in the areas of the brain that help to regulate the vomiting reflex. This can also control nausea and vomiting.

What happens if The Endocannabinoid system isn’t up to par?

“Homeostasis” is used a lot when referring to this system. It means the internal balance of the system. CBD is it works internally. If you have a broken leg you can feel and see the damage and you will do something to fix it via a cast and rest. We do not see the inflammation of our internal systems until the symptoms occur. Your body will find a new balance. You will get better but this is not its original balance.  The Endocannabinoid system should be helped to maintain balance. Prevention is better than cure. Your health truly is your wealth so look after it so you can avoid such issues as listed below.

Fibromyalgia, Irritable bowel disease, Migraines, Post-traumatic stress disorder, Bipolar disorder, and Schizophrenia.


Sleep Anxiety Stress And CBD
Sleep Anxiety Stress And CBD

The Good news for your The Endocannabinoid System

CBD is a great substance and it can have a very positive effect on your system. Supplementing this system daily with the correct dose of CBD can overcome the deficiency in the brain and other body sites.
There is a lot in the above to read and take in. The reason why it is one of the first things we wrote about is that having a simple understanding of this system means you know why you are taking it. What is your health worth to you? The price of a cup of coffee a day?


It is no wonder that Pharmaceutical companies fight against Hemp and Cannabis as treatments. It is hard to place a patent on a plant that naturally occurs in nature!!!

All material here has been sourced from various places and like all the blogs here are freely available to anyone to look up and research. I do not own any of this material and I cannot take credit for any of it. If I wanted to try and protect the material I could reference it and protect it in other ways. This is not an extremely difficult thing to do. Our main goal is to educate the consumer.

We hope you enjoyed reading about The Endocannabinoid system and if you have any questions or comments please let us know.

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